Human Sera
Cayman Chemical 3amInoLTyrosInhydrochlo 50mg
A tyrosine derivative; completely inhibits the growth of a tyrosine-sensitive mutant of N. crassa at 400 µM; cytotoxic to KG-1 leukemia cells at 200-400 UG/ml; dietary administration decreases fecundity and hatchability of eggs of B. oleae at 0.01 g/100 ml, as well as survival of adult B. oleae at 6 g/100 ml
Cayman Chemical R S-3 5-DHPG 50mg
An agonist of group I mGluRs; induces phosphoinositol hydrolysis in MCB3901 cells expressing human mGluR1a and mGluR5a; potentiates NMDA-induced depolarizations in rat hippocampal slices at 10 µM; intrathecal administration increases mean blood pressure in anesthetized rats at 300 nmol/animal; induces seizures in rats at 1.5 µmol/animal, i.c.v.
Cayman Chemical PIperacetazIn 50mg
A typical antipsychotic; inhibits spontaneous motor activity and responding for food in rats, as well as potentiates hexobarbital-induced narcosis in mice; inhibits lysosome acidification, as well as viral entry (IC50 = <8.5 µM), in Ebola-infected Huh7 cells
Cayman Chemical OlopatdInhydrochlorIde 50mg
A histamine H1 receptor antagonist (Ki =41 nM); 1,059- and 4,177-fold selective for histamine H1 over H2 and H3 receptors, respectively; inhibits histamine-induced phosphoinositide turnover in isolated human conjunctival epithelial cells, isolated human corneal fibroblasts, and human TM3 cells (IC50s = 9.5, 19, and 39.9 nM, respectively); inhibits passive cutaneous anaphylaxis in rats (ED50 = 49 UG/kg) and IgG1-mediated bronchoconstriction in ovalbumin-sensitized guinea pigs (ED50 = 30 UG/kg)
Cayman Chemical ClozapIn NoxIdehydrochLR 50mg
An MCT1 and MPC inhibitor inhibits lactate update in SiHa human cervix carcinoma cells (IC50 50 nM) inhibits proliferation of SiHa cells in the presence of lactate but not glucose inhibits MPC in isolated tumor cell mitochondria increases intratumor lactate accumulation and decreases tumor size in an SiHa mouse xenograft model at 3 mg/kg
Cayman Chemical Clofarabn 50mg
A nucleoside analog that inhibits ribonucleotide reductase and DNA polymerase-α (IC50s = 65 and 3.9 nM, respectively) and is cytotoxic to K562 myelogenous leukemia cells (IC50 = 5 nM) as well as various other leukemias and solid tumors
Cayman Chemical SecurInIn 100mg
An alkaloid; reduces proliferation of SW480 colon adenocarcinoma cells in a dose- and time-dependent manner; decreases viability of HL-60 leukemia cells (IC50s = 47.88, 23.85, and 18.87 μM at 24, 48, and 72 hours post-treatment, respectively); induces cell cycle arrest at the G1/S phase and decreases PI3K, Akt, and mTOR gene expression in a dose-dependent manner; inhibits GABA and GABA-activated benzodiazepine binding to rat brain membranes (IC50s = 57 and 101 μM, respectively); induces clonic and tonic convulsions in mice at 5.2 mg/kg
Cayman Chemical ZatebradInhydrochlorIde 50mg
Blocks If currents through HCN channels in sinoatrial node cells (IC50s = 1.83, 2.21, 1.9, and 1.88 µM, respectively for HCN1-4 in vitro); reduces heart rate from 600 to 200 beats per minute with an ED50 value of 1.8 mg/kg and induces increasing arrhythmia at concentrations >10 mg/kg when assessed through telemetric ECG recording in mice
Cayman Chemical EmtrIcItabIn 100mg
An antiviral nucleoside analog; an inhibitor of HIV-1 and hepatitis B reverse transcriptase; inhibits replication of HIV-1 (EC50s = 10-20 nM) and hepatitis B (EC50s = 10-40 nM) in various cell lines; inhibits duck hepatitis B viral DNA synthesis when administered pre- and post-viral inoculation in primary duck hepatocytes; reduces viremia and hepatic WHV replication in a dose-dependent manner in a woodchuck model of chronic WHV infection
Cayman Chemical -SulpIrIde 50mg
An atypical antipsychotic; binds to dopamine D2 and D3 receptors (Kis = 4.2 and 15 nM, respectively); selective for dopamine D2 and D3 over D1 receptors and 5-HT1A, 5-HT2A, 5-HT2C, and 5-HT3 receptors (Kis = >10,000 nM); increases attentional accuracy and decreases latency to respond correctly, the number of omissions, and impulsivity in the 5CSRTT in rats at 0.5 or 1 ng per animal; increases cortical and striatal demethylation of hypermethylated reelin and GAD67 promoters in mice from 12.5 to 50 μmol/kg twice per day for 3 days
Cayman Chemical AlmotrIptnmalate 50mg
An agonist of 5-HT1B and 5-HT1D receptors (IC50s = 12 and 13 nM, respectively, in a radioligand binding assay); selective for human 5-HT1B and 5-HT1D receptors over rat 5-HT1A and human 5-HT2A and 5-HT4 receptors (IC50s = 0.85, 25.1, and 140 μM, respectively); induces contractions in isolated canine saphenous veins (EC50 = 394 nM) but not isolated rabbit renal or mesenteric arteries; increases carotid vascular resistance in anesthetized cats (ED100 = 11 μg/kg, i.v.) without increasing blood pressure or heart rate
Cayman Chemical HArgGlyAspCysOHtrIfluo 100mg
An RGD-containing tetrapeptide; inhibits the binding of fibrinogen to endothelial cells and ADP-stimulated platelets (IC50s = 320 and 35 µM, respectively); implantation of titanium rods coated with H-Arg-Gly-Asp-Cys-OH increases bone formation in rat femurs; has been conjugated to polyethylenimine to improve gene transfection efficiency
Cayman Chemical Epmed folum Epmedn C 50mg
A flavonoid glycoside; scavenges DPPH radicals in a cell-free assay (IC50 = 142 µM); increases proliferation of UMR-106 osteoblasts by 30.4 and 41.6% at 0.1 and 10 µM, respectively; inhibits TPA-induced EAr edema in mice (ED50 = 192 nmol/ear)